Timothy Trotter
The overarching goal of my research is to characterize fundamental mechanisms of tolerance by which tumor cells evade adaptive immunity during metastasis and the latent phase before recurrence. I am particularly interested in how normal processes wherein immune tolerance is critical, such as wound healing and embryo implantation, are co-opted by tumor cells throughout the metastatic cascade for long-term survival. In addition, I recently identified DKK3 as a dormant tumor-derived factor that promotes regulatory T cells in the microenvironment and I am currently working to define precise pathways that mediate this function.
