Our lab investigates cancer immunology and inflammation, aiming to boost tumor-fighting defenses. We explore how cancers develop to thwart immunity, as well as how inflammation and immune responses influence cancer development and spread.
Additionally, we are investigating the use and development of different types of immunotherapy, vaccines, and targeted antibodies for use against cancer, with a focus on translating the approaches into effective patient treatments.
Zack C. Hartman
2024-01-24 11:43:36 - Anne Sacks joins the lab
This winter semester Anne Sacks (Trinity) began her independent studies in the lab
2024-01-08 11:43:36 - New Rotation Students in the lab
The Hartman lab welcomes Susannah Garber (Pharm) and Yu-Ming Li (IIB) as rotation students to the lab.
2023-12-31 00:00:00 - New Paper published in Human Vaccines and Immunotherapeutics
This study demonstrates the potential of ESR1 targeting vaccines against mutant ER+ Breast Cancer. Congrats Gabby and all!
Reporter immunogenicity as a defined rejection antigen: a noninvasive platform for skin transplant immunobiology.
Sydney Jeffs, John S Wang, Reshma Goud, Jackie No, Gerald Lorio, Guang Han Lin, Nicole Moon, Violet Y Tu, Timothy N Trotter, Zachary C Hartman, Tatiana Segura.
Front Immunol. 2026 Sep 1;17:1859500. doi: 10.3389/fimmu.2026.1859500. eCollection 2026.
Endogenous neoantigen-specific antibodies mediate antitumor responses and determine vaccine efficacy.
Sirajbir S Sodhi, John S Wang, David T Severson, Joey V Ragusa, Nicole Moon, Timothy Trotter, Li-Chung Tsao, Herbert Kim Lyerly, Zachary Conrad Hartman.
J Immunother Cancer. 2026 May 7;14(5):e014671. doi: 10.1136/jitc-2025-014671.
Development of a STEAP1-Targeted Prostate Cancer Specific Antibody Drug Conjugate Platform with Immunostimulatory Properties.
John Shuhan Wang, Sirajbir S Sodhi, Li-Chung Tsao, Guang Han Lin, Nicole Moon, Qiang Zhang, Bushangqing Liu, Juliet Penaranda, Timothy N Trotter, Jason A Somarelli, Andrew J Armstrong, H Kim Lyerly, Guangdi Wang, Zachary C Hartman.
Res Sq [Preprint]. 2026 Apr 24:rs.3.rs-9194287. doi: 10.21203/rs.3.rs-9194287/v1.
