Our lab investigates cancer immunology and inflammation, aiming to boost tumor-fighting defenses. We explore how cancers develop to thwart immunity, as well as how inflammation and immune responses influence cancer development and spread.
Additionally, we are investigating the use and development of different types of immunotherapy, vaccines, and targeted antibodies for use against cancer, with a focus on translating the approaches into effective patient treatments.
Zack C. Hartman
Jan 24, 2024 - Anne Sacks joins the lab
This winter semester Anne Sacks (Trinity) began her independent studies in the lab
Jan 08, 2024 - New Rotation Students in the lab
The Hartman lab welcomes Susannah Garber (Pharm) and Yu-Ming Li (IIB) as rotation students to the lab.
Dec 31, 2023 - New Paper published in Human Vaccines and Immunotherapeutics
This study demonstrates the potential of ESR1 targeting vaccines against mutant ER+ Breast Cancer. Congrats Gabby and all!
Vaccination Against Androgen Receptor Splice Variants to Immunologically Target Prostate Cancer.
Robert D Marek, Selena Halabi, Mu-En Wang, Jason McBane, Junping Wei, Tao Wang, Xiao Yang, Congxiao Liu, Gangjun Lei, Herbert Kim Lyerly, Ming Chen, Timothy N Trotter, Zachary C Hartman.
Vaccines (Basel). 2024 Nov 13;12(11):1273. doi: 10.3390/vaccines12111273.
Overcoming Xenoantigen Immunity to Enable Cellular Tracking and Gene Regulation with Immune-competent "NoGlow" Mice.
Timothy N Trotter, Andrea Wilson, Jason McBane, Carina E Dagotto, Xiao-Yi Yang, Jun-Ping Wei, Gangjun Lei, Hannah Thrash, Joshua C Snyder, Herbert Kim Lyerly, Zachary C Hartman.
Cancer Res Commun. 2024 Apr 9;4(4):1050-1062. doi: 10.1158/2767-9764.CRC-24-0062.
Vaccines targeting <em>ESR1</em> activating mutations elicit anti-tumor immune responses and suppress estrogen signaling in therapy resistant ER+ breast cancer.
Gabrielle P Dailey, Christopher A Rabiola, Gangjun Lei, Junping Wei, Xiao-Yi Yang, Tao Wang, Cong-Xiao Liu, Melissa Gajda, Amy C Hobeika, Amanda Summers, Robert D Marek, Michael A Morse, Herbert K Lyerly, Erika J Crosby, Zachary C Hartman.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2309693. doi: 10.1080/21645515.2024.2309693. Epub 2024 Feb 8.
