Our lab investigates cancer immunology and inflammation, aiming to boost tumor-fighting defenses. We explore how cancers develop to thwart immunity, as well as how inflammation and immune responses influence cancer development and spread.
Additionally, we are investigating the use and development of different types of immunotherapy, vaccines, and targeted antibodies for use against cancer, with a focus on translating the approaches into effective patient treatments.
Zack C. Hartman
Oct 02, 2023 - John Wang joins the lab
This year John Wang official began his 3rd medical school year, which is devoted to research in the lab
Sep 06, 2023 - Sushrit Pasumarthy joins the lab
This fall semester Sushrit Pasumarthy (Trinity) began his independent studies in the lab
Jul 12, 2023 - New Paper published in Cancer Gene Therapy
This review summarizes the use of self-replication RNA viruses as a platform for antitumor vaccine studies. Congrats Gabby and all!
Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd).
Li-Chung Tsao, John S Wang, Xingru Ma, Sirajbir Sodhi, Joey V Ragusa, Bushangqing Liu, Jason McBane, Tao Wang, Junping Wei, Cong-Xiao Liu, Xiao Yang, Gangjun Lei, Ivan Spasojevic, Ping Fan, Timothy N Trotter, Michael Morse, Herbert Kim Lyerly, Zachary C Hartman.
Nat Commun. 2025 Apr 2;16(1):3167. doi: 10.1038/s41467-025-58266-8.
Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancer.
Julio C Tinoco, Harmony I Saunders, Lauryn Rose Werner, Xiaopeng Sun, Eilidh I Chowanec, Amanda Heard, Prabhakar Chalise, Jeffery M Vahrenkamp, Andrea E Wilson, Cong-Xiao Liu, Gangjun Lei, Junping Wei, Hugo Cros, Hisham Mohammed, Melissa Troester, Charles Perou, Mary A Markiewicz, Jason Gertz, Justin M Balko, Zachary Conrad Hartman, Christy R Hagan.
J Immunother Cancer. 2025 Mar 18;13(3):e010179. doi: 10.1136/jitc-2024-010179.
Vaccination Against Androgen Receptor Splice Variants to Immunologically Target Prostate Cancer.
Robert D Marek, Selena Halabi, Mu-En Wang, Jason McBane, Junping Wei, Tao Wang, Xiao Yang, Congxiao Liu, Gangjun Lei, Herbert Kim Lyerly, Ming Chen, Timothy N Trotter, Zachary C Hartman.
Vaccines (Basel). 2024 Nov 13;12(11):1273. doi: 10.3390/vaccines12111273.
