Our lab investigates cancer immunology and inflammation, aiming to boost tumor-fighting defenses. We explore how cancers develop to thwart immunity, as well as how inflammation and immune responses influence cancer development and spread.
Additionally, we are investigating the use and development of different types of immunotherapy, vaccines, and targeted antibodies for use against cancer, with a focus on translating the approaches into effective patient treatments.
Zack C. Hartman
Jan 24, 2024 - Anne Sacks joins the lab
This winter semester Anne Sacks (Trinity) began her independent studies in the lab
Jan 08, 2024 - New Rotation Students in the lab
The Hartman lab welcomes Susannah Garber (Pharm) and Yu-Ming Li (IIB) as rotation students to the lab.
Dec 31, 2023 - New Paper published in Human Vaccines and Immunotherapeutics
This study demonstrates the potential of ESR1 targeting vaccines against mutant ER+ Breast Cancer. Congrats Gabby and all!
Endogenous neoantigen-specific antibodies mediate antitumor responses and determine vaccine efficacy.
Sirajbir S Sodhi, John S Wang, David T Severson, Joey V Ragusa, Nicole Moon, Timothy Trotter, Li-Chung Tsao, Herbert Kim Lyerly, Zachary Conrad Hartman.
J Immunother Cancer. 2026 May 7;14(5):e014671. doi: 10.1136/jitc-2025-014671.
Development of a STEAP1-Targeted Prostate Cancer Specific Antibody Drug Conjugate Platform with Immunostimulatory Properties.
John Shuhan Wang, Sirajbir S Sodhi, Li-Chung Tsao, Guang Han Lin, Nicole Moon, Qiang Zhang, Bushangqing Liu, Juliet Penaranda, Timothy N Trotter, Jason A Somarelli, Andrew J Armstrong, H Kim Lyerly, Guangdi Wang, Zachary C Hartman.
Res Sq [Preprint]. 2026 Apr 24:rs.3.rs-9194287. doi: 10.21203/rs.3.rs-9194287/v1.
Enhanced efficacy of a next-generation EEEV self-replicating RNA platform for combination cancer immunotherapies.
Shigeki J Miyake-Stoner, Christian J Maine, Annie C Chou, Gabrielle P Dailey, Darina S Spasova, Christine C Domingo, Jessica Sparks, Gaelle Picarda, H Kim Lyerly, Erika J Crosby, Andrew J Geall, Nathaniel S Wang, Zachary C Hartman, Parinaz Aliahmad.
Mol Ther. 2026 Mar 25:S1525-0016(26)00212-1. doi: 10.1016/j.ymthe.2026.03.026. Online ahead of print.
