Our lab investigates cancer immunology and inflammation, aiming to boost tumor-fighting defenses. We explore how cancers develop to thwart immunity, as well as how inflammation and immune responses influence cancer development and spread.
Additionally, we are investigating the use and development of different types of immunotherapy, vaccines, and targeted antibodies for use against cancer, with a focus on translating the approaches into effective patient treatments.
Zack C. Hartman
Jan 24, 2024 - Anne Sacks joins the lab
This winter semester Anne Sacks (Trinity) began her independent studies in the lab
Jan 08, 2024 - New Rotation Students in the lab
The Hartman lab welcomes Susannah Garber (Pharm) and Yu-Ming Li (IIB) as rotation students to the lab.
Dec 31, 2023 - New Paper published in Human Vaccines and Immunotherapeutics
This study demonstrates the potential of ESR1 targeting vaccines against mutant ER+ Breast Cancer. Congrats Gabby and all!
CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity.
Bin-Jin Hwang, Erika J Crosby, David T Severson, Timothy N Trotter, Jason McBane, Li-Chung Tsao, Tao Wang, Cong-Xiao Liu, Xiao-Yi Yang, Gangjun Lei, Junping Wei, Xingru Ma, Bushanqing Liu, Amy Hobeika, Michael Morse, Jesuchristopher Joseph, Ethan Agritelley, Elishama Kanu, Karrie Comatas, Tibor Keler, Li-Zhen He, Herbert Kim Lyerly, Zachary C Hartman.
Sci Immunol. 2025 Dec 19;10(114):eadz2294. doi: 10.1126/sciimmunol.adz2294. Epub 2025 Dec 19.
TuNa-AI: A Hybrid Kernel Machine To Design Tunable Nanoparticles for Drug Delivery.
Zilu Zhang, Yan Xiang, Joe Laforet, Ivan Spasojevic, Ping Fan, Ava Heffernan, Christine E Eyler, Kris C Wood, Zachary C Hartman, Daniel Reker.
ACS Nano. 2025 Sep 23;19(37):33288-33296. doi: 10.1021/acsnano.5c09066. Epub 2025 Sep 11.
Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd).
Li-Chung Tsao, John S Wang, Xingru Ma, Sirajbir Sodhi, Joey V Ragusa, Bushangqing Liu, Jason McBane, Tao Wang, Junping Wei, Cong-Xiao Liu, Xiao Yang, Gangjun Lei, Ivan Spasojevic, Ping Fan, Timothy N Trotter, Michael Morse, Herbert Kim Lyerly, Zachary C Hartman.
Nat Commun. 2025 Apr 2;16(1):3167. doi: 10.1038/s41467-025-58266-8.
