Overcoming Xenoantigen Immunity to Enable Cellular Tracking and Gene Regulation with Immune-competent "NoGlow" Mice.
Timothy N Trotter, Andrea Wilson, Jason McBane, Carina E Dagotto, Xiao-Yi Yang, Jun-Ping Wei, Gangjun Lei, Hannah Thrash, Joshua C Snyder, Herbert Kim Lyerly, Zachary C Hartman.
Cancer Res Commun. 2024 Apr 9;4(4):1050-1062. doi: 10.1158/2767-9764.CRC-24-0062.
Vaccines targeting <em>ESR1</em> activating mutations elicit anti-tumor immune responses and suppress estrogen signaling in therapy resistant ER+ breast cancer.
Gabrielle P Dailey, Christopher A Rabiola, Gangjun Lei, Junping Wei, Xiao-Yi Yang, Tao Wang, Cong-Xiao Liu, Melissa Gajda, Amy C Hobeika, Amanda Summers, Robert D Marek, Michael A Morse, Herbert K Lyerly, Erika J Crosby, Zachary C Hartman.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2309693. doi: 10.1080/21645515.2024.2309693. Epub 2024 Feb 8.
CEA vaccines.
Anchit Bhagat, Herbert K Lyerly, Michael A Morse, Zachary C Hartman.
Hum Vaccin Immunother. 2023 Dec 15;19(3):2291857. doi: 10.1080/21645515.2023.2291857. Epub 2023 Dec 13.
Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3.
Timothy N Trotter, Carina E Dagotto, Delila Serra, Tao Wang, Xiao Yang, Chaitanya R Acharya, Junping Wei, Gangjun Lei, H Kim Lyerly, Zachary C Hartman.
JCI Insight. 2023 Nov 22;8(22):e174458. doi: 10.1172/jci.insight.174458.
Beyond Neoantigens: Antigens Derived from Tumor Drivers as Cancer Vaccine Targets.
Erika J Crosby, Zachary C Hartman, H Kim Lyerly.
Clin Cancer Res. 2023 Sep 1;29(17):3256-3258. doi: 10.1158/1078-0432.CCR-23-1244.
Clinical trials of self-replicating RNA-based cancer vaccines.
Michael A Morse, Erika J Crosby, Jeremy Force, Takuya Osada, Amy C Hobeika, Zachary C Hartman, Peter Berglund, Jonathan Smith, H Kim Lyerly.
Cancer Gene Ther. 2023 Jun;30(6):803-811. doi: 10.1038/s41417-023-00587-1. Epub 2023 Feb 10.
Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers.
Kensuke Kaneko, Chaitanya R Acharya, Hiroshi Nagata, Xiao Yang, Zachary Conrad Hartman, Amy Hobeika, Philip F Hughes, Timothy A J Haystead, Michael A Morse, Herbert Kim Lyerly, Takuya Osada.
J Immunother Cancer. 2022 Sep;10(9):e004793. doi: 10.1136/jitc-2022-004793.
Cancer vaccine strategies using self-replicating RNA viral platforms.
Gabrielle P Dailey, Erika J Crosby, Zachary C Hartman.
Cancer Gene Ther. 2023 Jun;30(6):794-802. doi: 10.1038/s41417-022-00499-6. Epub 2022 Jul 12.
Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression.
Bin-Jin Hwang, Li-Chung Tsao, Chaitanya R Acharya, Timothy Trotter, Pankaj Agarwal, Junping Wei, Tao Wang, Xiao-Yi Yang, Gangjun Lei, Takuya Osada, Herbert Kim Lyerly, Michael A Morse, Zachary Conrad Hartman.
J Immunother Cancer. 2022 Mar;10(3):e003721. doi: 10.1136/jitc-2021-003721.
Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis.
Li-Chung Tsao, Erika J Crosby, Timothy N Trotter, Junping Wei, Tao Wang, Xiao Yang, Amanda N Summers, Gangjun Lei, Christopher A Rabiola, Lewis A Chodosh, William J Muller, Herbert Kim Lyerly, Zachary C Hartman.
JCI Insight. 2022 Mar 22;7(6):e155636. doi: 10.1172/jci.insight.155636.
HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.
Takuya Osada, Erika J Crosby, Kensuke Kaneko, Joshua C Snyder, Joshua D Ginzel, Chaitanya R Acharya, Xiao-Yi Yang, Thomas J Polascik, Ivan Spasojevic, Rendon C Nelson, Amy Hobeika, Zachary C Hartman, Leonard M Neckers, Andre Rogatko, Philip F Hughes, Jiaoti Huang, Michael A Morse, Timothy Haystead, H Kim Lyerly.
Mol Cancer Ther. 2022 Jan;21(1):217-226. doi: 10.1158/1535-7163.MCT-21-0334. Epub 2021 Oct 21.
How can we create precision immunotherapy as standard in breast cancer?.
Zachary C Hartman.
Expert Rev Anticancer Ther. 2021 Nov;21(11):1179-1181. doi: 10.1080/14737140.2021.1951241. Epub 2021 Jul 5.
Mechanisms of Therapeutic Antitumor Monoclonal Antibodies.
Li-Chung Tsao, Jeremy Force, Zachary C Hartman.
Cancer Res. 2021 Sep 15;81(18):4641-4651. doi: 10.1158/0008-5472.CAN-21-1109. Epub 2021 Jun 18.
HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase.
Joshua D Ginzel, Chaitanya R Acharya, Veronica Lubkov, Hidetoshi Mori, Peter G Boone, Lauren K Rochelle, Wendy L Roberts, Jeffrey I Everitt, Zachary C Hartman, Erika J Crosby, Lawrence S Barak, Marc G Caron, Jane Q Chen, Neil E Hubbard, Robert D Cardiff, Alexander D Borowsky, H Kim Lyerly, Joshua C Snyder.
Mol Cancer Res. 2021 Oct;19(10):1699-1711. doi: 10.1158/1541-7786.MCR-21-0215. Epub 2021 Jun 15.
Progesterone promotes immunomodulation and tumor development in the murine mammary gland.
Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Ying Hu, Junping Wei, Gangjun Lei, Xiao-Yi Yang, Rashna Madan, Alfredo A Molinolo, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Zachary C Hartman, Carol A Lange, Christy R Hagan.
J Immunother Cancer. 2021 May;9(5):e001710. doi: 10.1136/jitc-2020-001710.
Cancer vaccines: the importance of targeting oncogenic drivers and the utility of combinations with immune checkpoint inhibitors.
Erika J Crosby, H Kim Lyerly, Zachary C Hartman.
Oncotarget. 2021 Jan 5;12(1):1-3. doi: 10.18632/oncotarget.27861. eCollection 2021 Jan 5.
Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio.
Erika J Crosby, Amy C Hobeika, Donna Niedzwiecki, Christel Rushing, David Hsu, Peter Berglund, Jonathan Smith, Takuya Osada, William R Gwin Iii, Zachary C Hartman, Michael A Morse, Herbert Kim Lyerly.
J Immunother Cancer. 2020 Nov;8(2):e001662. doi: 10.1136/jitc-2020-001662.
Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer.
Erika J Crosby, Chaitanya R Acharya, Anthony-Fayez Haddad, Christopher A Rabiola, Gangjun Lei, Jun-Ping Wei, Xiao-Yi Yang, Tao Wang, Cong-Xiao Liu, Kay U Wagner, William J Muller, Lewis A Chodosh, Gloria Broadwater, Terry Hyslop, Jonathan H Shepherd, Daniel P Hollern, Xiaping He, Charles M Perou, Shengjie Chai, Benjamin K Ashby, Benjamin G Vincent, Joshua C Snyder, Jeremy Force, Michael A Morse, Herbert K Lyerly, Zachary C Hartman.
Clin Cancer Res. 2020 Sep 1;26(17):4670-4681. doi: 10.1158/1078-0432.CCR-20-0389. Epub 2020 Jul 30.
HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression.
Alan Chen Chen, Renhuan Xu, Tao Wang, Junping Wei, Xiao-Yi Yang, Cong-Xiao Liu, Gangjun Lei, Herbert Kim Lyerly, Teri Heiland, Zachary Conrad Hartman.
J Immunother Cancer. 2020 Jun;8(1):e000258. doi: 10.1136/jitc-2019-000258.
IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils.
Timothy N Trotter, Casey W Shuptrine, Li-Chung Tsao, Robert D Marek, Chaitanya Acharya, Jun-Ping Wei, Xiao-Yi Yang, Gangjun Lei, Tao Wang, Herbert Kim Lyerly, Zachary C Hartman.
Cancer Res. 2020 Aug 1;80(15):3088-3100. doi: 10.1158/0008-5472.CAN-18-3825. Epub 2020 May 4.
CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis.
Li-Chung Tsao, Erika J Crosby, Timothy N Trotter, Pankaj Agarwal, Bin-Jin Hwang, Chaitanya Acharya, Casey W Shuptrine, Tao Wang, Junping Wei, Xiao Yang, Gangjun Lei, Cong-Xiao Liu, Christopher A Rabiola, Lewis A Chodosh, William J Muller, Herbert Kim Lyerly, Zachary C Hartman.
JCI Insight. 2019 Dec 19;4(24):e131882. doi: 10.1172/jci.insight.131882.
T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes.
Tomasz Kula, Mohammad H Dezfulian, Charlotte I Wang, Nouran S Abdelfattah, Zachary C Hartman, Kai W Wucherpfennig, Herbert Kim Lyerly, Stephen J Elledge.
Cell. 2019 Aug 8;178(4):1016-1028.e13. doi: 10.1016/j.cell.2019.07.009.
Vaccine-Induced Memory CD8<sup>+</sup> T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study.
Erika J Crosby, William Gwin, Kimberly Blackwell, Paul K Marcom, Serena Chang, Holden T Maecker, Gloria Broadwater, Terry Hyslop, Sungjin Kim, Andre Rogatko, Veronica Lubkov, Joshua C Snyder, Takuya Osada, Amy C Hobeika, Michael A Morse, H Kim Lyerly, Zachary C Hartman.
Clin Cancer Res. 2019 May 1;25(9):2725-2736. doi: 10.1158/1078-0432.CCR-18-3102. Epub 2019 Jan 11.
Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy.
H Kim Lyerly, Takuya Osada, Zachary C Hartman.
Clin Cancer Res. 2019 Jan 1;25(1):9-11. doi: 10.1158/1078-0432.CCR-18-2819. Epub 2018 Oct 30.
Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.
Takuya Osada, Zachary C Hartman, Junping Wei, Gangjun Lei, Amy C Hobeika, William R Gwin, Marcio A Diniz, Neil Spector, Timothy M Clay, Wei Chen, Michael A Morse, H Kim Lyerly.
Breast Cancer Res. 2018 Aug 9;20(1):90. doi: 10.1186/s13058-018-1023-x.
Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors.
Erika J Crosby, Junping Wei, Xiao Yi Yang, Gangjun Lei, Tao Wang, Cong-Xiao Liu, Pankaj Agarwal, Alan J Korman, Michael A Morse, Kenneth Gouin, Simon R V Knott, H Kim Lyerly, Zachary C Hartman.
Oncoimmunology. 2018 Jan 19;7(5):e1421891. doi: 10.1080/2162402X.2017.1421891. eCollection 2018.
<em>In Vivo</em> Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior.
Takuya Osada, Kensuke Kaneko, William R Gwin, Michael A Morse, Amy Hobeika, Brian W Pogue, Zachary C Hartman, Philip F Hughes, Timothy Haystead, H Kim Lyerly.
Clin Cancer Res. 2017 Dec 15;23(24):7531-7542. doi: 10.1158/1078-0432.CCR-17-1453. Epub 2017 Oct 9.
An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection.
Casey W Shuptrine, Reham Ajina, Elana J Fertig, Sandra A Jablonski, H Kim Lyerly, Zachary C Hartman, Louis M Weiner.
Cancer Immunol Immunother. 2017 Dec;66(12):1529-1544. doi: 10.1007/s00262-017-2047-2. Epub 2017 Aug 2.
Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy.
Jun Ren, William R Gwin, Xinna Zhou, Xiaoli Wang, Hongyan Huang, Ni Jiang, Lei Zhou, Pankaj Agarwal, Amy Hobeika, Erika Crosby, Zachary C Hartman, Michael A Morse, Kevin H Eng, H Kim Lyerly.
Oncoimmunology. 2016 Dec 7;6(4):e1264563. doi: 10.1080/2162402X.2016.1264563. eCollection 2017.
Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
Abhijit Mazumdar, Graham M Poage, Jonathan Shepherd, Anna Tsimelzon, Zachary C Hartman, Petra Den Hollander, Jamal Hill, Yun Zhang, Jenny Chang, Susan G Hilsenbeck, Suzanne Fuqua, C Kent Osborne, Gordon B Mills, Powel H Brown.
Breast Cancer Res Treat. 2016 Aug;158(3):441-54. doi: 10.1007/s10549-016-3892-y. Epub 2016 Jul 8.
The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.
J Turpin, C Ling, E J Crosby, Z C Hartman, A M Simond, L A Chodosh, J P Rennhack, E R Andrechek, J Ozcelik, M Hallett, G B Mills, R D Cardiff, J W Gray, O L Griffith, W J Muller.
Oncogene. 2016 Nov 24;35(47):6053-6064. doi: 10.1038/onc.2016.129. Epub 2016 May 9.
Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
Jing Zhao, Dekuang Zhao, Graham M Poage, Abhijit Mazumdar, Yun Zhang, Jamal L Hill, Zachary C Hartman, Michelle I Savage, Gordon B Mills, Powel H Brown.
J Clin Invest. 2015 Jul 1;125(7):2707-20. doi: 10.1172/JCI70805. Epub 2015 Jun 15.
Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.
Jared J Barrott, Philip F Hughes, Takuya Osada, Xiao-Yi Yang, Zachary C Hartman, David R Loiselle, Neil L Spector, Len Neckers, Narasimhan Rajaram, Fangyao Hu, Nimmi Ramanujam, Ganesan Vaidyanathan, Michael R Zalutsky, H Kim Lyerly, Timothy A Haystead.
Chem Biol. 2013 Sep 19;20(9):1187-97. doi: 10.1016/j.chembiol.2013.08.004. Epub 2013 Sep 12.
Revealing targeted therapeutic opportunities in triple-negative breast cancers: a new strategy.
Graham M Poage, Zachary C Hartman, Powel H Brown.
Cell Cycle. 2013 Sep 1;12(17):2705-6. doi: 10.4161/cc.25871. Epub 2013 Jul 30.
Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.
Zachary C Hartman, Graham M Poage, Petra den Hollander, Anna Tsimelzon, Jamal Hill, Nattapon Panupinthu, Yun Zhang, Abhijit Mazumdar, Susan G Hilsenbeck, Gordon B Mills, Powel H Brown.
Cancer Res. 2013 Jun 1;73(11):3470-80. doi: 10.1158/0008-5472.CAN-12-4524-T. Epub 2013 Apr 30.
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.
Jessica D Kessler, Kristopher T Kahle, Tingting Sun, Kristen L Meerbrey, Michael R Schlabach, Earlene M Schmitt, Samuel O Skinner, Qikai Xu, Mamie Z Li, Zachary C Hartman, Mitchell Rao, Peng Yu, Rocio Dominguez-Vidana, Anthony C Liang, Nicole L Solimini, Ronald J Bernardi, Bing Yu, Tiffany Hsu, Ido Golding, Ji Luo, C Kent Osborne, Chad J Creighton, Susan G Hilsenbeck, Rachel Schiff, Chad A Shaw, Stephen J Elledge, Thomas F Westbrook.
Science. 2012 Jan 20;335(6066):348-53. doi: 10.1126/science.1212728. Epub 2011 Dec 8.
Increasing vaccine potency through exosome antigen targeting.
Zachary C Hartman, Junping Wei, Oliver K Glass, Hongtao Guo, Gangjun Lei, Xiao-Yi Yang, Takuya Osada, Amy Hobeika, Alain Delcayre, Jean-Bernard Le Pecq, Michael A Morse, Timothy M Clay, Herbert K Lyerly.
Vaccine. 2011 Nov 21;29(50):9361-7. doi: 10.1016/j.vaccine.2011.09.133. Epub 2011 Oct 12.
Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors.
Wenle Xia, Zuguo Liu, Rongrong Zong, Leihua Liu, Sumin Zhao, Sarah S Bacus, Yubin Mao, Jia He, Julia D Wulfkuhle, Emanuel F Petricoin, Takuya Osada, Xiao-Yi Yang, Zachary C Hartman, Timothy M Clay, Kimberly L Blackwell, Herbert K Lyerly, Neil L Spector.
Mol Cancer Ther. 2011 Aug;10(8):1367-74. doi: 10.1158/1535-7163.MCT-10-0991. Epub 2011 Jun 14.
HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis.
Zachary C Hartman, Xiao-Yi Yang, Oliver Glass, Gangjun Lei, Takuya Osada, Sandeep S Dave, Michael A Morse, Timothy M Clay, Herbert K Lyerly.
Cancer Res. 2011 Jul 1;71(13):4380-91. doi: 10.1158/0008-5472.CAN-11-0308. Epub 2011 Apr 25.
Polyclonal immune responses to antigens associated with cancer signaling pathways and new strategies to enhance cancer vaccines.
Timothy M Clay, Takuya Osada, Zachary C Hartman, Amy Hobeika, Gayathri Devi, Michael A Morse, H Kim Lyerly.
Immunol Res. 2011 Apr;49(1-3):235-47. doi: 10.1007/s12026-010-8186-6.
Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity.
Zachary C Hartman, Takuya Osada, Oliver Glass, Xiao Y Yang, Gang-Jun Lei, H Kim Lyerly, Timothy M Clay.
Cancer Res. 2010 Sep 15;70(18):7209-20. doi: 10.1158/0008-5472.CAN-10-0905. Epub 2010 Sep 7.
Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.
Sergey S Seregin, Yasser A Aldhamen, Daniel M Appledorn, Zachary C Hartman, Nathaniel J Schuldt, Jeannine Scott, Sarah Godbehere, Haixiang Jiang, Michael M Frank, Andrea Amalfitano.
Blood. 2010 Sep 9;116(10):1669-77. doi: 10.1182/blood-2010-03-276949. Epub 2010 May 28.
Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor.
Sergey S Seregin, Zachary C Hartman, Daniel M Appledorn, Sarah Godbehere, Haixiang Jiang, Michael M Frank, Andrea Amalfitano.
J Innate Immun. 2010;2(4):353-9. doi: 10.1159/000284368. Epub 2010 Feb 11.
Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector Ad5 [E1-, E2b-]-CEA.
Elizabeth S Gabitzsch, Younong Xu, Joseph P Balint, Zachary C Hartman, H Kim Lyerly, Frank R Jones.
Cancer Immunol Immunother. 2010 Jul;59(7):1131-5. doi: 10.1007/s00262-010-0847-8. Epub 2010 Apr 2.
An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity.
Zachary C Hartman, Junping Wei, Takuya Osada, Oliver Glass, Gangjun Lei, Xiao-Yi Yang, Sharon Peplinski, Dong-Wan Kim, Wenle Xia, Neil Spector, Jeffrey Marks, William Barry, Amy Hobeika, Gayathri Devi, Andrea Amalfitano, Michael A Morse, H Kim Lyerly, Timothy M Clay.
Clin Cancer Res. 2010 Mar 1;16(5):1466-77. doi: 10.1158/1078-0432.CCR-09-2549. Epub 2010 Feb 23.
Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccine.
Takuya Osada, Christopher Y Woo, Matthew McKinney, Xiao Yi Yang, Gangjun Lei, Heather G Labreche, Zachary C Hartman, Donna Niedzwiecki, Nelson Chao, Andrea Amalfitano, Michael A Morse, H Kim Lyerly, Timothy M Clay.
Clin Cancer Res. 2009 Apr 15;15(8):2789-96. doi: 10.1158/1078-0432.CCR-08-2589. Epub 2009 Apr 7.
Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity.
T Osada, X Y Yang, Z C Hartman, O Glass, B L Hodges, D Niedzwiecki, M A Morse, H K Lyerly, A Amalfitano, T M Clay.
Cancer Gene Ther. 2009 Sep;16(9):673-82. doi: 10.1038/cgt.2009.17. Epub 2009 Feb 20.
The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.
Todd J Cohen, Tomasa Barrientos, Zachary C Hartman, Sean M Garvey, Gregory A Cox, Tso-Pang Yao.
FASEB J. 2009 Jan;23(1):99-106. doi: 10.1096/fj.08-115931. Epub 2008 Sep 9.
Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system.
Zachary C Hartman, Daniel M Appledorn, Delila Serra, Oliver Glass, Todd B Mendelson, Timothy M Clay, Andrea Amalfitano.
Virology. 2008 May 10;374(2):453-67. doi: 10.1016/j.virol.2008.01.017. Epub 2008 Feb 15.
Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications.
Zachary C Hartman, Daniel M Appledorn, Andrea Amalfitano.
Virus Res. 2008 Mar;132(1-2):1-14. doi: 10.1016/j.virusres.2007.10.005. Epub 2007 Nov 26.
Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo.
Zachary C Hartman, Anne Kiang, Ruth S Everett, Delila Serra, Xiao Y Yang, Timothy M Clay, Andrea Amalfitano.
J Virol. 2007 Feb;81(4):1796-812. doi: 10.1128/JVI.01936-06. Epub 2006 Nov 22.
Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells.
Zachary C Hartman, Esther P Black, Andrea Amalfitano.
Virology. 2007 Feb 20;358(2):357-72. doi: 10.1016/j.virol.2006.08.041. Epub 2006 Oct 5.
Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.
Anne Kiang, Zachary C Hartman, Ruth S Everett, Delila Serra, Haixiang Jiang, Michael M Frank, Andrea Amalfitano.
Mol Ther. 2006 Oct;14(4):588-98. doi: 10.1016/j.ymthe.2006.03.024. Epub 2006 Jun 2.
Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice.
Anne Kiang, Zachary C Hartman, Shaoxi Liao, Fang Xu, Delila Serra, Donna J Palmer, Philip Ng, Andrea Amalfitano.
Mol Ther. 2006 Jan;13(1):127-34. doi: 10.1016/j.ymthe.2005.08.006. Epub 2005 Oct 5.
