Selena Halabi
In collaboration with graduate student RD Marek, I am investigating androgen receptor and androgen receptor splice variants (AR-Vs) as potential immunological targets for castration-resistant prostate cancer. I previously generated murine prostate cancer cell lines that express murine homologs of AR-Vs to develop an immunocompetent, tolerized model of prostate cancer. I am now evaluating the ability of novel mRNA and srRNA vaccine candidates to induce a T cell mediated anti-tumor immune response against neoepitopes from AR-Vs.
